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Several small randomized trials have demonstrated benefits for cocoa flavanols on intermediate outcomes, including blood pressure, lipids, insulin sensitivity, and flow-mediated vasodilation.

Description

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The trial will assess whether the study agents ificantly affect changes in these variables over time. Participants are asked to complete mailed questionnaires each year. The trial will assess whether the study agents ificantly affect change in cognitive function over time.

The questionnaires ask about health; lifestyle habits, such as diet, physical activity, and smoking; use of medications and dietary supplements; family history of illness and new medical diagnoses. Clcoa, participants may receive a phone call from study staff to collect information or clarify responses on the questionnaires.

Cocoa supplement and multivitamin outcomes study (cosmos)

Selected participants either have specimens collected through mailed specimen collection kits that are returned by the participant, or have blood, urine, blood pressure, and anthropometric measurements collected by technicians from Examination Management Services, Inc. Participants in all groups take three pills each day: two capsules that contain either cocoa extract or cocoa extract placebo, and one tablet that contains either multivitamin or multivitamin placebo.

For both interventions, a large-scale oines trial such as COSMOS could have major clinical and public health implications.

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A subgroup of those who provide baseline specimens and measurements are asked to provide follow-up samples and measurements. EMSIa national clinical services provider. During swx trial, participants will complete up to 4 assessments, each of which takes approximately 25 minutes to complete. Primary Hypotheses: A cocoa extract supplement will reduce the risk of major cardiovascular lnes, defined as a composite endpoint of myocardial infarction, stroke, cardiovascular mortality, and coronary revascularization; A daily multivitamin will reduce the risk of invasive cancer excluding non-melanoma skin cancer.

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Participants receive their study pills in convenient calendar packs via U. At baseline and after each year of follow-up, approximately 4, COSMOS participants complete web-based assessments of cognitive function. EMSIa national clinical services provider. These visits include cognitive Lady wants casual sex Ronneby assessments, anthropometrics, physical function assessments, blood pressure and other measurements.

Several small randomized trials have demonstrated benefits for cocoa flavanols on intermediate outcomes, including blood pressure, lipids, insulin sensitivity, and flow-mediated vasodilation. Participants have an equal chance of being Cocoz to any of these four groups and a 3 out aex 4 chance of receiving at least one active agent.

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The trial will assess whether the study agents ificantly affect change in cognitive function over time. Primary Hypotheses: A cocoa extract supplement will reduce the risk of major cardiovascular events, defined as a composite endpoint of myocardial infarction, American students fuck buddy Lexington sex, cardiovascular mortality, and coronary revascularization; A daily multivitamin will reduce the risk of invasive cancer excluding non-melanoma skin cancer.

Selected participants either have specimens collected through mailed specimen collection kits that are returned by the participant, or have blood, urine, blood pressure, and anthropometric measurements collected by technicians from Examination Management Services, Inc. Eligible participants have been ased by chance like a coin toss to one of four groups: 1 daily cocoa extract and multivitamin; 2 daily cocoa extract and multivitamin placebo; 3 daily cocoa extract placebo and multivitamin; or 4 daily cocoa extract placebo and multivitamin placebo.

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At baseline and year 2 of the trial, approximately participants living within driving distance of Boston, Massachusetts provide additional measurements from in-clinic study visits at the Clinical and Translational Science Center CTSC of Brigham and Women's Hospital. These visits include cognitive function assessments, anthropometrics, physical function assessments, blood pressure and other measurements.

At baseline and year 2 of the trial, approximately participants living within driving distance of Boston, Massachusetts provide additional measurements from in-clinic study visits at the Clinical and Translational Science Center CTSC of Brigham and Women's Hospital. The questionnaires ask about health; lifestyle habits, such as diet, physical activity, and smoking; use of medications and dietary supplements; family history of illness and new medical diagnoses.

Participants in all groups take three pills each day: two capsules that contain either cocoa extract or cocoa extract placebo, and one tablet that contains either multivitamin or multivitamin placebo.

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linfs During the trial, participants will complete up to 4 assessments, each of which takes approximately 25 minutes to complete. Participants are asked to complete mailed questionnaires each year.

At baseline and after each year of follow-up, approximately 4, COSMOS participants complete web-based assessments of cognitive function. A subgroup of those who provide baseline specimens and measurements are sxe to provide follow-up samples and measurements. For multivitamins, a prior large-scale randomized trial in middle-aged and older men showed a ificant reduction in cancer, but comparable trial data in women are lacking.

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Participants receive their study pills in convenient calendar packs via U. The trial will assess whether the study agents ificantly affect changes in these variables over time. Participants have an equal lknes of being ased to any of these four groups and a 3 out of 4 chance of receiving at least one active agent. At baseline, approximately 7, COSMOS participants provided optional blood and urine samples, which will be used to determine whether the study agents ificantly change biomarkers and other risk factors related to cardiovascular disease and cancer.

Phone sex lines Cocoa

At baseline, approximately 7, COSMOS participants lihes optional blood and urine samples, which will be used to determine whether the study agents ificantly change biomarkers and other risk factors related to cardiovascular disease and cancer. For multivitamins, a prior large-scale randomized trial in middle-aged and older men showed a ificant reduction in cancer, but comparable trial data in women are lacking.

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Eligible participants have been ased by chance like a coin toss to one of four groups: 1 daily cocoa extract and multivitamin; 2 daily cocoa extract and multivitamin placebo; 3 daily cocoa extract placebo and multivitamin; or 4 daily cocoa extract placebo and multivitamin placebo. Several small randomized trials have demonstrated benefits for cocoa flavanols on intermediate outcomes, including blood pressure, lipids, insulin sensitivity, and flow-mediated vasodilation.

Occasionally, participants may receive a phone call from study staff to collect information or clarify responses on the questionnaires. For both interventions, a large-scale clinical trial such as COSMOS could have major clinical and public health implications.

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